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Moon et al suggested a hypothesis that GLP-1 Thr 13 interacts with a binding pocket formed by Ile 196 , Leu 232 , and Met 233 of GLP-1R because Thr 7 -containing chimeric peptides are highly sensitive for the Ile 196 mutation

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Comparing both to semaglutide (Ozempic/Wegovy) Any conversation about retatrutide versus Mounjaro would be incomplete without placing both in the context of semaglutide, the drug that started the GLP-1 weight loss revolution