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These drugs were originally developed to treat Type 2 diabetes, but they have gained popularity for their significant weight loss effects, helping people lose 15% to 20% of their body weight in clinical trials

After 72 weeks, participants on Zepbound lost an average of 20.2% of their body weight (averaging 50 pounds), compared to 13.7% (around 33 pounds) for those on the 2.4 mg dose of Wegovy (later studies of the 7.2 mg dose of Wegovy have showed 18.7% weight loss)

For patients receiving tirzepatide through mail-order pharmacies, the medication should be refrigerated immediately upon receipt

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Additionally, if you've had pancreatitis in the past, caution is advised as GLP-1 medications have been associated with an increased risk of this painful condition

The apparent discrepancy between memory performance in the MWM and locomotor outcomes in the OF likely reflects the distinct behavioral demands of the tasks: whereas MWM performance emphasizes hippocampal-dependent spatial memory with a more aversive nature considering the life-threatening aspects associated with the need to find the safe dry space (ie: platform), the OF more directly captures locomotor capacity and exploratory drive that are impacted by anxiety and stress levels, which may be preferentially restored by sustained dual-target modulation through the nanoparticle system