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Discontinuation rates due to adverse events ranged from 5.3% to 10.3% across orforglipron dose groups, compared to 2.7% in the placebo group

To achieve optimal results, injections should consistently be on the same day each week

For military personnel, these insights may help explain why certain GLP-1 doses or formulations might align better with individual physiology, enabling more precise provider discussion around military fitness timelines and deployment readiness

This process is outlined in detail within DoD 1010.16, Technical Procedures for the Military Personnel Drug Abuse Testing Program

There are several different GLP-1 medications currently approved for weight loss in people with obesity, including: Liraglutide and semaglutide are GLP-1 receptor agonist medications, while tirzepatide is a dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist medication

NPs play a key role in addressing these barriers, advocating for patients, and promoting informed, stigma-free discussions that support safe and equitable use