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The SURMOUNT-5 trial (published in NEJM, 2025) demonstrated mean weight loss of 20.2% with tirzepatide versus 13.7% with semaglutide over 72 weeks in adults with obesity but without diabetes [10]

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Liang, L

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Increased insulin secretion is induced by picomolar doses of GLP-1 through mechanisms that are dependent on PKC

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Most patients experience initial rapid loss during weeks 112, with a natural plateau emerging between months 6 and 12 as your body adapts to semaglutide

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It can also be hard to eat more even if you know you need the calories when youre already feeling full or nauseated

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But that number did not appear at week 8 or week 12

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