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Description
The SURMOUNT-5 trial (published in NEJM, 2025) demonstrated mean weight loss of 20.2% with tirzepatide versus 13.7% with semaglutide over 72 weeks in adults with obesity but without diabetes [10]
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Liang, L

Increased insulin secretion is induced by picomolar doses of GLP-1 through mechanisms that are dependent on PKC

Most patients experience initial rapid loss during weeks 112, with a natural plateau emerging between months 6 and 12 as your body adapts to semaglutide
It can also be hard to eat more even if you know you need the calories when youre already feeling full or nauseated

But that number did not appear at week 8 or week 12
