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Intestinal adaptation to cold-induced metabolic demand and feeding requires GLP-1R and GLP-2R signalling

This central fat distribution carries higher cardiometabolic risks (things that raise your chance of heart disease or diabetes) compared to weight distributed elsewhere on the body

The resulting elimination half-life of approximately 13 h supports a once-daily dosing regimen [19]

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Rather than eliminating fat entirely, which would be nutritionally inadequate, focus on distributing fat intake evenly throughout the day in moderate amounts

Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS