recombinant glp 1 Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency Targeting GLP-1, GIP & GCG

The class of drugs, which includes Novo Nordisks Ozempic and Wegovy, are associated with the risk of gastrointestinal adverse events when used for weight loss, finds a study published Thursday in JAMA.

GLP-1 medications like semaglutide and tirzepatide show mixed effects on gastrointestinal symptoms, with potential benefits for some IBS patients but also the risk of worsening symptoms in others

Physicians can legally prescribe GLP-1 receptor agonists for weight management in eligible patients, though prescribing patterns vary

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