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Despite this complexity, current treatments predominantly focus on BMI thresholds with little consideration for individual phenotypes or response variability ( Comorbidities BMI is currently the primary criterion for prescribing weight loss medications with thresholds of 30 kg/m for general obesity and 27 kg/m for those with comorbidities

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The GLP-1 peptide (a short chain of amino acids) is secreted by cells in the small intestine, but it is also synthesized in the brain

If semaglutide isn't curbing your hunger after 2-3 months of consistent use, your genetic profile may simply predict lower sensitivity to this particular medication target