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Consistent with this, exendin-P5, which induces faster kinetics in G protein activation and cAMP production, exhibits higher cAMP efficacy than GLP-1 and exendin-4, as indicated by a greater pEC 50 /pIC 50 ratio when comparing cAMP and binding studies 13

This sustained presence in the bloodstream contributes to the medications ability to maintain glycemic control and promote weight reduction throughout the weekly dosing cycle

CagriSema achieved 20.4% weight loss at 68 weeks in REDEFINE 1