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Glucagon, besides antagonizing the action of insulin, also induces gluconeogenesis and inappropriately raised glucagon secretion in T1DM patients contributed directly to increased hepatic glucose output and worsening of postprandial glucose control as well as variability of glycemia 18

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[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Sandforth A, et al

GLP-1R-targeted nanomedicines often carry multifunctional payloads, such as GLP-1 analogs, chemotherapeutic agents, and diagnostic compounds, which do not conform to conventional monotherapy trial frameworks [558, 559]

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Patients who are taking concomitant diabetes medications should monitor their blood sugars closely and be prepared to treat hypoglycemia (see hypoglycemia for more) Injection site reactions Injection site reactions, including pruritus, erythema, inflammation, induration, and irritation, may occur