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Pharmacological 5-Aminoimidazole-4-carboxamide riboside 5-Aminoimidazole-4-carboxamide riboside (AICAR) was the first compound identified to activate AMPK

Liraglutide activated the Nrf2/HO-1 pathway and protected cerebral neurons against stroke in diabetic rats (109)

Many clinical trials have reported gastrointestinal side effects as among the most common side effects of GLP-1 receptor agonists, contributing to decreased fluid intake

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These medications work primarily through pancreatic and central nervous system pathways