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By virtue of their molecular structure, ephedrine and pseudoephedrine stimulate adrenergic receptors at cavernous vein plexuses, determining its nasal decongestant effect [57]

Just hold gentle pressure for 10-15 seconds

Newsome NP, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V, et al

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This also represents the contrast between investigator initiated and governmental agency funded trials (TOPCAT, SPIREN, BARACK-D) in which the eligibility/enrolment were messed up or not achieved, interventions were completely missed or dropped out early, and possibly many other gaps and slips