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It plays a key role in post-meal glucose control by increasing insulin secretion and suppressing glucagon levels

Preclinical data on the mechanisms of potential sex differences in the endogenous GLP-1 system as well as the therapeutic effect of GLP-1 analogs, focusing on the effects of the drugs on the brain and behavior relating to appetite and metabolism, are highlighted

In protective immunity, DPP4 is involved in T cell activation and proliferation, crucial for defending against pathogens, and influences cytokine production, affecting the immune responses nature and strength

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GLP-1 activation communicates feelings of fullness to the brain, aiding in smaller meal satisfaction, while GIP activation enhances sugar processing and insulin regulation

Innovative designs incorporating active comparators, adaptive frameworks, and biomarker-driven endpoints (e.g., CSF/serum NfL, p-tau, microglial PET, synaptic markers) will be critical to generate interpretable efficacy signals