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This effect can support efforts to moderate calorie intake as part of a structured approach to weight management

Taking Ozempic or Wegovy without a medical diagnosis just to lose weight is not an official use

Approval of the research protocol The meta-analysis was registered in PROSPERO, with registration number CRD42023460291

This includes adults with an initial BMI of 30 kg/m 2 and above, or 27 to 29.9 kg/m 2 with at least one weight-associated comorbidity (e.g hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease, prediabetes or T2DM)

The results of the subgroup analyses stratified by age, baseline HbA1c, duration of diabetes, and cardiovascular risk status are shown in Supplementary Figs

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