do glp 1 drugs cause depression The risk of depression, anxiety, and suicidal behavior in patients with obesity on glucagon like peptide-1 receptor agonist therapy GLP-1 Agonists Can Be Heaven

Haqq L, McFarlane J, Dieberg G, Smart N

In vitro studies on bone cells supported the expression of the conventional GLP-1R in osteoblasts and confirmed that liraglutide, at nanomolar concentrations, promoted osteoblast differentiation and reduced osteoblast apoptosis via activation of the PI3K/Akt/GSK3K, MAPK, and cAMP/PKA/-catenin intracellular pathways [46,47,48]

What They Are and Why Lifestyle Change Is Key to Sustained Weight Loss Mayo Clinic : Cleveland Clinic: Crohn's Disease Mount Sinai: GLP-1 Medications: Reimagining the Treatment Paradigm for Severe Crohns Disease Crohn's & Colitis Foundation: Key Insights from Crohns & Colitis Congress 2025: Revolutionary Research, Pregnancy Considerations, AI Innovations, and More Harvard Health Publishing: Do GLP-1 Drugs Reduce Inflammation

Ghasemi R, Haeri A, Dargahi L, Mohamed Z, Ahmadiani A

As our collaborators at Cure Parkinsons note in this post, many people with Parkinsons also have glucose intolerance or diabetes

This indicates that safety signals are more visible in pooled short-term RCTs, while long-term adherence and the risks of weight rebound or metabolic withdrawal post-discontinuation remain difficult to quantify reliably in existing studies