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Description
Major conclusions Since its discovery, GLP-1 has emerged as a pleiotropic hormone with a myriad of metabolic functions that go well beyond its classical identification as an incretin hormone
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I think most people think about these processes in terms of a single, ideal bound conformation of the peptide to the receptor as the basis for signalling, says Gellman, but Im increasingly suspecting that certain modes of dynamics are critical for signalling. He is now trying to design this structural variability into his hybridtides to see if this will improve on the performance of GLP-1 drugs
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Framework of study design for cost effectiveness analysis

Amgen has completed a phase 1 trial with a dual agonist that includes GLP-1

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