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While long-term studies are still limited, current evidence suggests that low doses used properly over extended periods are unlikely to cause harm in healthy adults

Higher doses produce increased incidence and severity of gastrointestinal symptoms, which explains why clinical protocols use gradual dose escalation starting at 0.25 mg weekly and incrementally increasing every 4 weeks

Consistent with this, GIP promotes clearance of circulating TAGs in dogs (168) and enhances adipose tissue TAG accumulation in rats (169) and humans (170)

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Consequently, many patients may be at risk for adverse effects and uncertain longterm outcomes related to the use of these drugs

If you experience significant gastrointestinal adverse effects, your doctor may recommend pausing or reducing the dose