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Intracerebroventricular application of GLP-1R agonist binds to GLP-1R on both neurons and astrocytes in the NTS

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Zhao C, Dahlman-Wright K

PVT GLP-1R agonism by intra-injections of Ex-4, reduces food intake, food-motivation, and food-seeking, while blocking GLP-1R signaling with PVT Ex-9 injection, increases meal size and food intake [36]