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Acute Pancreatitis Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including OZEMPIC [see Adverse Reactions (6 )]

Understanding these medication-specific challenges allows healthcare providers to implement proactive nutritional strategies

Clinical trials included patients with BMI 27 kg/m with comorbidities or BMI 30 kg/m, and efficacy was demonstrated across this spectrum

For this reason, it is subject to a potentially dramatic increase in systemic exposure and associated higher risk of overdose with grapefruit as a result of diminished CYP3A4 activity, primarily in the small intestine rather than in the liver