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It enhances the production of non-amyloidogenic forms of APP and inhibits the activity of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), a key enzyme involved in A production, thereby reducing A levels [182, 186,187,188]

Whilst they work through different mechanisms, their combined effects on blood glucose levels and metabolic processes warrant careful consideration, particularly in individuals with diabetes or pre-diabetes

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If you have diabetes and need to discontinue your medication, your healthcare provider will help you develop an alternative plan for managing your blood glucose levels, as sudden discontinuation may affect glycemic control