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However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics

C., Haas, B

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La semaglutida oral fue superior a placebo y otros frmacos antihiperglucemiantes, como los iDPP4 (sitagliptina), los iSGLT2 (empagliflozina) u otros arGLP-1 (liraglutida) para reducir la HbA1c o el peso116

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