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GLP-1 medications (semaglutide, tirzepatide, etc.) have helped

Hypothalamic dysfunction is a common finding in PWS and it has been implicated in several manifestations of this syndrome such as hyperphagia, temperature instability, high pain threshold, sleep disordered breathing, and multiple endocrine abnormalities

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Women should discontinue Ozempic at least 2 months before attempting to conceive, as explicitly stated in the FDA prescribing information