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126 Co-administration of warfarin (a substrate of CYP1A2, CYP2C9, and CYP3A4) and octreotide led to high INR levels in humans, which may be attributed to the increased warfarin exposure caused by octreotides inhibitory effect on CYP3A4

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For those with low strength, further assessment of muscle mass (such as bioelectrical impedance analysis and dual-energy X-ray absorptiometry) is conducted, and the severity is defined by physical manifestations (such as walking speed and the Brief Physical Condition Scale) [2, 3]