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If theres one that your insurance does cover, then great, well start with that one. Trials have shown that on average tirzepatide leads to more weight loss than semaglutide, but different patients respond differently to different GLP-1 drugs

Gradual dose increases are key to improving tolerability

Evidence Review GLP-1 receptor agonists are medications licensed in the UK for type 2 diabetes and obesity management

Previous research had suggested people typically regain lost weight within a year of stopping weight-loss drugs, but this is the first analysis to calculate the rate of regain and estimate how long it takes for weight and metabolic health to fully reverse

Preclinical studies with SAR425899 clearly demonstrated dual receptor agonism in vitro and in preclinical in vivo studies, with a higher potency for the GLP1R than for the glucagon receptor in order to counterbalance the GCGR mediated increase of blood glucose levels through GLP-1 agonism 11,12,13