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Trial Registration The predefined protocol has been registered in PROSPERO having registration number of CRD42023473991

#TRANSCENDT2D1 trial : A new era in the treatment of #Type2Diabetes The TRANSCEND-T2D-1 trial provides compelling evidence that #retatrutide, a first-in-class triple GIP/GLP-1/glucagon receptor agonist, may redefine expectations for the treatment of Type 2 DM

Cognitive function was tested using the National Institute of Health Toolbox Cognitive Battery at baseline and 12 weeks

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To unlock wider and more equitable access to novel obesity treatments, however, positive cardiovascular outcomes data will be absolutely critical to demonstrate substantial cost-savings for health systems from medication-assisted weight loss by avoiding downstream complications from obesity-related comorbidities