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GLP-1 receptors exist in brain regions involved in reward, motivation, and eating behavior

In the United States, retatrutide is not a scheduled controlled substance and can be legally purchased as a research chemical for legitimate research use

Zhang XP, Hintze TH

For the nutritional management of type 2 diabetes

High-throughput screening campaigns against the GLP-1 receptor and other class B GPCRs consistently yielded low hit rates for small molecules, and the few hits that emerged typically showed micromolar potency, insufficient for therapeutic applications