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Description
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The effects of GLP-1 and dual agonists on lipid metabolism also provide a more complete treatment plan for metabolic diseases
Endogenous GLP-1R signaling exerts a physiologically relevant effect on BP control, which may be attributable, in part, to its tonic actions on proximal tubule Na/H mediated sodium reabsorption, and the intrarenal renin-angiotensin II system [67]
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Materials and methods Antibodies and reagents PC2 antibody (D1E1S), t-PKA antibody (D38C6), p-PKA antibody (D45D3), Pdx1 antibody (D59H3), GLP-1R antibody (HA500204) and all secondary antibodies used in Western blot were purchased from Cell Signaling Technology (Beverly, MA, United States)
Overall, liraglutide appeared to restore -cell responsiveness to physiological hyperglycaemia without unwanted insulin secretion at euglycaemia
