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Persistent high glucose levels have been linked to decreased testosterone levels, in part due to the downregulation of vascular endothelial growth factor (VEGF), which compromises testicular microcirculation, leading to Leydig cell dysfunction and blunted testosterone synthesis [64]

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This makes it impractical for routine clinical use, necessitating the development of modified GLP-1 receptor agonists like semaglutide

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It is available through research peptide suppliers at costs ranging from $150 to $400 per month