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Higher IGF-1 promotes: Lipolysis the breakdown of stored fat, particularly visceral fat Lean mass preservation reduced muscle catabolism Improved glucose metabolism better insulin sensitivity at the cellular level Enhanced lipid clearance lower triglycerides, improved lipid profiles Monitoring IGF-1 during tesamorelin therapy is not optional

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The role of GLP-1/GIP receptors: tirzepatide imbalanced and biased activation Human atrial and ventricular cardiomyocytes express the GLP1R within each of all chambers, and the sinoatrial (SA) node shows the highest level of GLP1R expression [11, 12]

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