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About this article Cite this article Dutta, D., Nagendra, L., Joshi, A

How It Works Activates both GLP-1 and GIP receptors for a broader metabolic impact Reduces appetite and increases satiety through two hormonal pathways Enhances insulin sensitivity more aggressively than GLP-1 alone Supports reduction of visceral fat the deep abdominal fat most strongly associated with metabolic disease Improves blood sugar regulation through a dual insulin-stimulating mechanism Clinical Results In the SURMOUNT-1 trial, Tirzepatide produced average weight loss of up to 20% of body weight outperforming Semaglutide in head-to-head comparisons

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Before starting, she recommended telling your doctor if you have a history of pancreatitis, slow stomach emptying (gastroparesis), past bariatric or stomach surgery, diabetic eye disease, or gallbladder problems such as gallstones

Blood was collected in heparinised syringes and placed in a tube with a mixture of DPP-4 inhibitor (Millipore, Burlington, MA, USA), heparin, EDTA and aprotonin