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Description
The STEP 1 trial (Wilding et al., NEJM, 2021) reported 14.9% mean weight reduction at 68 weeks on semaglutide 2.4 mg weekly, which remains the reference efficacy figure researchers cite when modelling the incremental benefit of GIP, glucagon, or amylin co-agonism

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Study design, progress and performance
BMC endocrine disorders, 22(1), 93

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