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Although we focused on non-diabetic individuals with overweight and obesity, potential confounding factors such as concomitant medications, baseline gastrointestinal conditions, and varying lifestyle factors could have influenced the incidence and severity of reported adverse events

Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity

Funding Statement The authors did not receive support from any organization for the submitted work

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Pre-existing gastrointestinal disorders, particularly functional dyspepsia or irritable bowel syndrome, appear to predispose patients to more pronounced GI symptoms

During periods of significant illness or dehydration, patients should seek medical advice and may need to temporarily interrupt GLP-1 treatment to reduce the risk of acute kidney injury and electrolyte imbalances