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, June 23, 2023 Chugai, Shizuoka, JP / Eli Lilly, Indianapolis, IN Orforglipron is the first oral, non-peptide GLP-1 receptor partial agonist approved by the FDA for obesity, with a regulatory filing in type 2 diabetes expected in 2026

Most patients report that nausea peaks within the first 1-2 weeks and gradually improves as the body acclimates to the medication

Digital Health Tools Wearables tracking glucose levels (e.g., continuous monitors) and AI-driven apps predicting cravings are entering clinics

While this effect contributes to weight loss and glycemic control by prolonging satiety and moderating glucose excursions, it can also produce gastrointestinal symptoms and affect perioperative care
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