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In line with our short-term metabolic analyses, previous studies in New Zealand obese and diet-induced obese male mice suggested that GLP1/E acts primarily at central levels to reverse metabolic alterations by decreasing food intake and body weight, while the potential beneficial effects on pancreatic beta-cells were possibly secondary and indirectly-mediated 33,48

Discontinuation rates due to side effects stayed in the low-to-mid teens, in line with other oral GLP-1s, Lilly said

Randomised and non-randomised studies were included

Here are the key results from landmark trials that established its clinical credibility

10.1007/s11481-024-10142-w 19 DruckerD

The next section of this review will discuss the interplay between GLP-1RAs and different types of cancers (Fig