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And when side effects persist beyond the typical 4-6 week adjustment period, switching to an alternative with a different receptor binding profile or mechanism of action often resolves the issue entirely

Its therapeutic potential, as extensively reviewed by Nauck et al

25 Conclusions Understanding the enteroinsular axis has been the basis of seminal advancements in the therapeutic approach to diabetes management, with translation of research discoveries into effective pharmacologic therapies

Diabetes (2014) 63(12):426274

As discussed below, the development of unimolecular multi-agonists that stimulate GLP-1 receptors and other receptors such as GIP receptors and glucagon receptors (GCGR) can have beneficial effects on metabolism and increase metabolic rate at tolerable doses [57]

This hormone plays a key role in regulating blood sugar, appetite, and digestion