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Introduction The remarkable growth in the use of Glucagon-Like Peptide-1 receptor agonists (GLP-1 RAs) in recent years has drawn attention to a class of drugs that have proven to be highly effective in managing type 2 diabetes mellitus (T2DM) and mitigating the effects of its numerous complications

As a result, many prevention programs have been implemented, but scientists have also discovered and introduced new medications for treating both conditions

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For instance, combining SGLT2 inhibitors or GLP-1 agonists with metformin can lower systolic blood pressure by 3 to 5 mmHg

It delays gastric emptying and activates GLP-1R-expressing neurons in the hypothalamus (arcuate nucleus) to reduce appetite

Elashoff et al., 2011)