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Plasma renin concentration remained unchanged

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Endothelial dysfunction is a significant component of HFpEF pathophysiology, and glucagon-like peptide-1 receptor (GLP-1R) agonists have shown potential benefits in improving endothelial function

Phase two trials of the US biotech companys obesity pill showed weight loss of 12.2 percent but a higher rate of patient drop-off compared to a placebo.

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Understanding this connection helps explain why these medications support metabolic health beyond weight loss alone