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Biochem Pharmacol (2010) 80:172735

These therapies work by increasing insulin secretion, slowing gastric emptying, and reducing appetite
In particular, the nucleus of the solitary tract (NTS) is a key brain region involved in the processing of autonomic and HPA axis stress responses [15, 16]

Berberine Action: Improves insulin sensitivity, regulates blood sugar, supports gut microbiota indirectly stimulates GLP-1 Dosage: 500 mg 2-3 times a day (before meals) Efficacy: Equivalent to metformin (a diabetes medication) in some studies 2

Although these effects are typically mild and temporary, they can influence a patients willingness to continue treatment [25]
Seek Medical Advice Dont ignore ongoing digestive issues