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And they did find the gene for glucagon, and they were surprised to discover that the same gene that makes glucagon also makes two other small peptides

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To identify the cellular pool of DPP-4 critical for the reduction of postprandial lipid excursion, we studied (a) mice with whole-body germline inactivation of Dpp4 ( Dpp4 / ), (b) mice with targeted inactivation of Dpp4 in Tie2 + endothelial and hematopoietic cells ( Dpp4 EC/ ), and (c) mice with inactivation of Dpp4 selectively in Villin + cells ( Dpp4 Gut/ ) (20)

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Furthermore, our in vivo study also showed that co-administration of the two drugs in HFD-fed ApoE / mice had add-on effects in improving vascular endothelial function and enhancing aortic p-eNOS protein level