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The most commonly reported symptoms include: Cycle changes: Heavier periods, longer periods, shorter cycles, irregular cycles Physical changes: Weight gain, sore breasts, changes in libido, vaginal dryness Sleep changes: More frequent waking, difficulty getting to sleep, insomnia Mood changes: More frequent mood changes, irritability, rage and increased PMS Vasomotor changes: Onset of night sweats, hot flushes New allergy symptoms: Hayfever-type symptoms or the onset of new allergies What's Happening to Our Hormones over the Four Stages of Perimenopause

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As of February 18, 2026, the class has expanded with established agents like semaglutide, liraglutide, dulaglutide, and exenatide, alongside dual GLP-1/GIP agonists such as tirzepatide, which are often discussed in GLP-1 contexts due to overlapping mechanisms and indications

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