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Individuals who are immunocompromised, critically ill, or recovering from surgery appear to be at particularly high risk for these complications (561)

Key biomarkers include C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and disease-specific markers like anti-CCP and rheumatoid factor, which define disease activity and treatment response

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Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE

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For some individuals, these effects may support appetite control and help with weight-management efforts when combined with appropriate nutrition and lifestyle changes