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Pharmacol Ther 121(3):294316 El K, Douros JD, Willard FS, Novikoff A, Sargsyan A, Perez-Tilve D, Wainscott DB, Yang B, Chen A, Wothe D, Coupland C, Tschop MH, Finan B, DAlessio DA, Sloop KW, Muller TD, Campbell JE (2023) The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

29 This discrepancy may suggest once more that animal models may differ from settings in humans, making extrapolations from animals to humans difficult