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63 Considering that T2DM and MASLD can reciprocally cause and affect each other, and given liraglutides potential therapeutic characteristics for MASLD, which may be beneficial for anti-fibrosis, more aggressive use of higher doses may bring greater clinical benefits in some groups, such as those with higher-grade fibrosis with or without T2DM

Conclusion GLP-1 medications work by slowing digestion and reducing appetite, but these mechanisms can lead to gastrointestinal (GI) side effects for as many as 40% of patients

Mordi IR, Singh S, Rudd A et al (2018) Comprehensive Echocardiographic and Cardiac Magnetic Resonance Evaluation Differentiates Among Heart Failure With Preserved Ejection Fraction Patients, Hypertensive Patients, and Healthy Control Subjects

Feeling cold is not among the most common side effects

Per the TrumpRx site, it is expected to launch in January 2026

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