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Serious Risks While rare, there are potential serious risks associated with GLP-1 medications: Pancreatitis: Inflammation of the pancreas, which requires immediate medical attention

However, recent observations and clinical studies have raised concerns regarding the potential association between GLP-1 RA use and the risk of pancreatic cancer [1,2]

Take the Next Step Toward a Healthier Future If youve struggled with weight for years or feel stuck despite consistent effort, GLP-1 therapy may offer the support you need

Examples of GLP-1 Medications Some well-known GLP-1 receptor agonists include: Semaglutide (e.g., Ozempic, Wegovy) Liraglutide (e.g., Victoza, Saxenda) Exenatide (e.g., Byetta, Bydureon) Dulaglutide (e.g., Trulicity) These medications are often used in managing type 2 diabetes and obesity due to their dual benefits in blood sugar control and weight loss

Thus, our results support conducting preclinical studies of semaglutide (and other GLP1R agonist) on THC and randomized clinical trials to evaluate the therapeutic benefits of semaglutide in CUD in individuals with obesity or T2D as well as in patients with CUD who dont have these co-morbid conditions

Changes in the gut microbiota may reduce the integrity of the intestinal barrier leading to increased leakage of lipopolysaccharides and fatty acids that act on TLR4 to activate systemic inflammation