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A realistic expectation for a well-managed program is 1-2 pounds per week on average during the first several months, with total loss in the 15-20% range over 12-18 months for patients who stay consistent

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As background to the study the investigators said, Emerging evidence suggests that even slightly elevated intracranial pressure (ICP) can exacerbate migraine by reducing intracranial compliance and increasing trigeminal pathway sensitization

Because GLP-1 agents can reduce insulin requirements, patients may inadvertently lower their insulin dose too much

Sources: Harvard Health Publishing

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