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There is increasing interest in whether and how GLP-1 medicines impact adipose tissue, muscle, and bone, questions with important clinical implications, especially in individuals who may be frail and experiencing rapid and substantial weight loss

Investigations Physical examination, laboratory studies including measurement of serum calcium and parathyroid hormone levels, measurement of urine and serum osmolalities before and after desmopressin administration, blood and urine cultures, and a CT scan of the abdomen

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