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Remarkably, microglia have a typical neurodegenerative signature for conditions such as Alzheimer's disease (AD), multiple sclerosis (MS), or Parkinson's disease (PD) (Butovsky and Weiner, 2018), reacting to injury through morphological changes by increasing microglial proliferation, migration to the target, phagocytosis, activating the inflammasome, and releasing proinflammatory molecules (Diz-Chaves et al., 2022b)

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Despite advances in medical interventions, the recurrence of stroke, particularly in patients with comorbid conditions like diabetes mellitus and obesity, is alarmingly high
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