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Other concerning symptoms that necessitate medical consultation include: Severe abdominal distension or inability to pass gas/stool (possible ileus or bowel obstruction) Nausea that worsens rather than improves after 812 weeks Inability to maintain adequate nutrition or hydration Unintentional weight loss exceeding clinical targets New or worsening heartburn or reflux symptoms Visual changes (especially with rapid blood sugar improvement) Severe headache or altered mental status Signs of gallbladder disease (right upper quadrant pain, especially after eating) Hypoglycemia symptoms if taking insulin or sulfonylureas Patients should generally not discontinue GLP-1 medications without medical guidance, except in emergencies such as suspected pancreatitis or severe allergic reaction
Cost-effectiveness analysis comparing retatrutide to existing therapies will heavily influence coverage decisions
10.1056/NEJMoa1305889 63
Burak: Thanks, Mark
Why do cravings return after stopping GLP-1 medications
Acid Stability: Gastric acidity destabilizes their molecular structure
