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2.5 Weighting: empwt (firms), empwt_a6 (firms, including those answering only the offer question), wkrwt (workers), covwt (policyholders), hmowt , ppowt , poswt , and hdpwt (plan weights) 2.6 Variance estimation: Taylor Series Linearization with newcell used as the stratum variable but no PSU variable

We hypothesised that the metabolite GLP-1(936) (previously believed to be biologically inactive) exerts a direct inhibitory effect on glucagon secretion and that this mechanism becomes impaired in diabetes

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Phase Phase 2 Early maintenance Weeks Weeks 58 Dose 5 mg once weekly Notes First true maintenance dose

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Tirzepatide percentages are approximate from published SURMOUNT-1 data