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The mechanistic rationale for GIPR agonism alongside GLP-1R agonism was initially counterintuitive, given that GIP had been considered therapeutically inert in T2DM due to documented GIP resistance

What type of exercise, you ask

For instance, in the DURATION-8 trial [36], once-weekly exenatide in combination with once-daily dapagliflozin did not lead to major hypoglycemia episodes over 104 weeks of treatment, with few events of minor hypoglycemia (1.7%)

2017;15(3):e13249

GLP-1RAs modulated alcohol-induced behavior by activating GLP-1Rs in reward-related areas and in the hindbrain

Crossover design constraints: A two-week washout may not have been sufficient