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Nauck MA, Horowitz M

In peripheral tissues, GIP receptor activation in adipocytes promotes lipid storage under fed conditions but may facilitate lipolysis when insulin levels are low, a nuanced effect that remains an active area of investigation in metabolic research [5]

In addition, injections avoid many of the drug interactions commonly seen with oral medications, including ones that interfere with absorption in the gut and reduce how well the medicine works

The STEP trials (Semaglutide Treatment Effect in People with obesity) tested weekly semaglutide at 2.4 mg (a higher dose than for diabetes) in people with obesity (BMI 30 or 27+comorbidity)